Principles of antibody-mediated TNF receptor activation

Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNF -Mediated NF- B Activation

of TNFR1 leads to the recruitment of the death domain (DD)-containing adaptor molecule TNFR1-associated death domain protein (TRADD), which serves as a platDaniel F. Legler,1,2,* Olivier Micheau,1 Marie-Agnès Doucey,1 Jürg Tschopp,1 and Claude Bron1 form to recruit additional mediators (Hsu et al., 1995, Institute of Biochemistry 1996). TRADD, in turn, binds the DD-containing Ser/ University of...

Serotonin 5-HT2A Receptor Activation Blocks TNF-α Mediated Inflammation In Vivo

Tumor necrosis factor alpha (TNF-α) plays a key role in inflammation, and its production and signaling contribute to many inflammatory related diseases. Recently, we discovered that selective activation of serotonin 5-HT2A receptors with the agonist (R)-DOI produces a super-potent blockade of proinflammatory markers in primary rat aortic smooth muscle cells. Here, we demonstrate that systemic a...

Role of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) in distinct and overlapping CD40 and TNF receptor 2/CD120b-mediated B lymphocyte activation.

Members of the tumor necrosis factor receptor (TNFR) family play a variety of roles in the regulation of lymphocyte activation. An important TNFR family member for B cell activation is CD40. CD40 signals stimulate B cell TNF-alpha secretion, which subsequently signals via TNFR2 (CD120b) to enhance B cell activation. Although the function of the pro-apoptotic and pro-inflammatory receptor TNFR1 ...

Respiratory Burst TNF-Induced Activation of Neutrophil Role of the 75-kDa TNF Receptor in

Effect of Cannabinoid Receptor Activation on Spreading Depression

Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods T...